Öz
Amaç
Erkek osteopeni ve osteoporoz hastalarında kemik mineral dansitesi (KMD), vücut kitle indeksi (VKİ) ve abdominal yağ yüzdesi arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem
Tek merkezli kesitsel çalışmaya 50-75 yaş arası toplam 156 erkek hasta dahil edildi (86 osteopeni, 70 osteoporoz). Demografik, antropometrik ve laboratuvar verileri kaydedildi. KMD ve abdominal yağ yüzdesi çift enerjili X-ışını absorbsiyometrisi ile ölçüldü. Gruplar t-testi veya Mann-Whitney U testi ile karşılaştırıldı. Spearman korelasyonu ve VKİ kategorilerine göre alt grup analizleri yapıldı.
Bulgular
Osteoporoz grubunda boy, kilo, VKİ ve abdominal yağ yüzdesi osteopeni grubuna göre anlamlı olarak daha düşüktü. Laboratuvar parametreleri benzer bulundu. Abdominal yağ yüzdesi lomber T-skoru ve femur total KMD ile zayıf fakat pozitif ilişkiliydi. VKİ tüm iskelet bölgelerinde KMD ile pozitif koreleydi. C-reaktif protein femur total KMD ile ters, abdominal yağ yüzdesi ile pozitif ilişkiliydi. VKİ’ye göre stratifikasyonda abdominal yağ yüzdesi yalnızca normal kilolu erkeklerde femur boynu (r=0.275; p=0.042) ve femur total KMD (r=0.374; p=0.005) ile pozitif ilişkili bulundu; fazla kilolu veya obezlerde ilişki gözlenmedi.
Sonuç
Bulgular, yağ dokusu ile kemik sağlığı arasında VKİ’ye bağlı çift fazlı bir ilişki olduğunu göstermektedir. Orta düzeyde abdominal yağ, normal kilolu erkeklerde daha yüksek KMD ile ilişkili olabilirken, fazla kilolu ve obezlerde enflamatuvar mekanizmalar bu faydayı azaltabilir veya ortadan kaldırabilir.
Anahtar Kelimeler:
Erkek osteoporozu, osteopeni, abdominal yağ, vücut kitle indeksi, kemik mineral dansitesi
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