Öz
Amaç
Bu çalışmada, sistemik immün enflamasyon indeksinin (SII), romatoid artrit (RA) hastalarında hastalık aktivitesini değerlendirmedeki yararlılığı araştırıldı.
Gereç ve Yöntem
Çalışmaya yaşları 18-65 arasında değişen 104 RA hastası ile 69 sağlıklı gönüllü dahil edildi. RA hastaları, hastalık aktivite skoru-28 (DAS-28-ESR skoru) <2,6 olan remisyon grubuna (n=51) ve >2,6 olan aktif RA grubuna (n=53) olmak üzere ikiye ayrıldı. SII ile enflamatuvar belirteçler ve hastalık aktivite indeksleri arasındaki ilişkiler analiz edildi. RA hastalık aktivitesinin değerlendirilmesinde SII’nın tanısal gücünü belirlemek amacıyla alıcı çalışma karakteristik eğrisi analizi uygulandı.
Bulgular
SII düzeyleri, hem genel RA grubunda hem de aktif hastalık grubunda anlamlı olarak yüksekti (p<0,001). SII; C-reaktif protein (rs=0,627, p<0,001), ESR (rs=0,383, p<0,001), DAS28-ESR (rs=0,775, p<0,001), simplifiye hastalık aktivite indeksi (rs=0,796, p<0,001) ve klinik hastalık aktivite indeksi (rs=0,798, p<0,001) ile pozitif yönde anlamlı korelasyon gösterdi. RA hastalık aktivitesini belirlemede SII için en uygun eşik değerin 479,36×109/L olduğu belirlendi (eğri altında kalan alan: 0,968; %95 güven aralığı: 0,914-0,993; duyarlılık: %92,45; özgüllük: %86,27).
Sonuç
SII, romatoid artritli hastalarda hastalık aktivitesini değerlendirmek için değerli ve erişilebilir bir belirteç gibi görünmektedir.
Anahtar Kelimeler:
Eritrosit sedimentasyon hızı, romatoid artrit, sistemik immün-enflamasyon indeksi
Kaynaklar
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